VCP takes out the trash

OTU takes the chains OUT.

ERα LBD structures may explain instability in the absence of ligand or with specific ligands 1,2,7,9. Nettles et al. 5 address this instability through use of a specific point mutation, Y537S, which stabilizes H12 in an agonist con-formation and is shown to overcome misfold-ing of the apo-ERα LBD. One might predict that stabilizing H12 on top of the ligand binding cavity with the Y537S mutation...

WASP takes the sting out of SCAR mutants

WASP takes the sting out of SCAR mutants V eltman et al. reveal how one actin regulator can fi ll in for another to maintain cell protrusion and migration. The Arp2/3 complex stimulates actin assembly at several different sites within the cell. WASP family proteins activate the complex at clathrin-coated pits undergoing endocytosis, whereas SCAR/WAVE proteins stimulate Arp2/3's activity at the ...

Reducing gravity takes the bounce out of running.

In gravity below Earth-normal, a person should be able to take higher leaps in running. We asked 10 subjects to run on a treadmill in five levels of simulated reduced gravity and optically tracked centre-of-mass kinematics. Subjects consistently reduced ballistic height compared with running in normal gravity. We explain this trend by considering the vertical take-off velocity (defined as maxim...

How Multi-site Businesses Have Turned Taking out the Trash from Cost Center to Profit Generator

Trash Compaction

Let P be a set of n objects on a square grid. A push is a transformation of P that involves sweeping a horizontal or vertical line by one unit, starting from the hull of P , displacing objects in the direction of the sweep. For example, when pushing to the right, all the leftmost objects are displaced one unit to the right. This in turn displaces other objects further right. Given P , we want t...